Chinese herbs help clear antibiotic resistant Heliobacter pylori infection after failure of triplet therapy with vonaprazan

Heliobacter pylori is a bacteria that is found in many patients with stomach ulcers and gastritis. Almost 50% of the world’s population are believed to have H.pylori in their stomach , but  many do not have any of the unpleasant symptoms that are associated with gastritis and do not develop ulcers. However for the people suffering from these health problems the eradication of H.Pylori is a critical part of the treatment.

Like many other strains of bacteria. Some strains of H.Pylori are becoming extremely resistant to antibiotics. This limits conventional treatment options for some patients.

Chinese herbs are powerful antibacterial weapons and viable alternatives to current antibiotic protocols . Chinese Herbs also can be used in conjunction with antibiotics to help overcome the drug resistance.

A recent journal article published in Journal of Digestive diseases, reported that a traditional formulation of Wu Zhu Yu Tang has helped eradicate a drug resistant H.Pylori infection when used on combination with antibiotic drugs.

We desperately need more research in using Chinese botanicals for antibiotic resistant bacteria. Drug resistant bacteria infections are on the increase and like climate change it is a global problem that requires us to think outside the box and beyond our own biases . We must work together for solutions for our future and not be solely be influenced  by politics and profit.


Vonoprazan, a potassium-competitive acid blocker, is used as a substitute drug for conventional proton pump inhibitors. Recently, vonoprazan has been applied for eradication of H. pylori (HP) infection, and the efficacies of vonoprazan-based triple therapy against HP infection have already been reported. However, treatment sometimes fails in the primary and/or secondary triplet eradication therapy, including with the use of vonoprazan for HP infection. We experienced three cases of refractory HP infection. They were treated with eradication therapy for HP infection with chronic gastritis. After primary triplet therapy with amoxicillin, clarithromycin, and rabeprazole (Case 1) or vonoprazan (Case 2, 3), their urea breath test were positive. Subsequently, patients received secondary eradication therapy with amoxicillin, metronidazole, and vonoprazan (Case 1, 2) or rabeprazole (Case 3), but their urea breath test was still positive. Thereafter, they consulted Kampo treatment. Kampo eradication therapy was given consisting of goshuyuto 2.5 g three-times daily plus rabeprazole 10 mg twice daily for 28 days. Finally, their urea breath test became negative. We successfully treated these cases with goshuyuto and rabeprazole. Goshuyuto treatment is worth trying as another therapeutic option.




Nagata, Y., Nagasaka, K., Koyama, S., Murase, M., Saito, M., Yazaki, T., Komatsu, N., Murase, T., Uehara, T. and Taniuchi, N. (), Successful eradication of Helicobacter pylori with a herbal medicine, goshuyuto (Wu Zhu Yu Tang), plus rabeprazole after failure of triplet therapy with vonoprazan: a report of three cases. Journal of Digestive Diseases. Accepted Author Manuscript. doi:10.1111/1751-2980.12537



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